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Glossary: Collagen
 


Definition
The primary protein within white fibers of connective tissue and the organic substance found in tendons, ligaments, cartilage, skin, teeth and bone.

Topics Related To Collagen
Alport SyndromeRelated Topic
"Alport syndrome is caused by a mutation in a gene for collagen..."

Ankylosing Spondylitis

The Condition
"Ankylosing spondylitis is an autoimmune disease which affects collagen structures, specifically the joints between the vertebrae of the spine..."

Atherosclerosis

Recommendation L-Proline
"Proline is involved in the structural repair of damaged collagen in arteriosclerotic blood vessels (hardened arteries)..."

Recommendation Hawthorn Berry Extract
"...Proanthocyanadins stabilize collagen to prevent cholesterol deposits on arterial walls, prevent free radical damage, reduce peripheral vascular resistance, angina, cholesterol, and increase coronary and myocardial perfusion;..."

Bilberry

As A Treatment
"...The actions of concentrated extracts have been shown to be effective in stabilizing collagen, normalizing capillary permeability, preventing platelet aggregation, and relaxing smooth muscles among other things..."

Bioflavonoids

As A Treatment
"...They assist Vitamin C in keeping collagen, the intercellular "cement" in healthy condition; are essential for the proper absorption and use of vitamin C; prevent Vitamin C from being destroyed in the body by oxidation; are beneficial..."

Carnosine

As A Treatment
"...Carnosine helps to prevent skin collagen cross-linking which leads to loss of elasticity and wrinkles..."

Cigarette Smoke Damage

Relationship to Buerger's Disease
"...Recent work suggests that Buerger's disease may be a reaction to tobacco of persons with a specific genetic type or an autoimmune disorder with immune cell sensitivity to some collagen types, which are constituents of blood vessels..."

Collagenosis

Related Topic
"A disease affecting collagen..."

Concern Over Wrinkled Skin

The Condition
"...into two main layers: the exterior epidermis, including the stratum corneum ("horny" outer layer), and the dermis below, which contains capillaries, hair follicles, sebaceous glands and the fibers (collagen and elastin) that give the skin its strength and elasticity..."

Relationship to Cigarette Smoke Damage
"...It decreases the formation of collagen, the skin's main structural component, and may reduce the water content of the skin, all of which increase wrinkling..."

Recommendation Vitamin C (Ascorbic Acid)
"...Ascorbic acid increases the synthesis of collagen more than five-fold in cultures of human skin..."

Copper

Related Topic
"...It is also involved with vitamin C in the formation of collagen and the proper functioning in central nervous system..."

Copper Deficiency

The Condition
"...Low copper levels may also affect collagen formation and thus tissue health and healing..."

Cosmetics / Moisturizers

As A Treatment
"...face="Arial" color="0000FF">SourceIngredients that are often added to moisturizers include lanolin (from sheep's wool, it may cause an allergic reaction), vitamins, essential fatty acids, collagen, elastin, and keratin..."

Elastin

Related Topic
"A protein that is similar to collagen and is the chief constituent of elastic fibers..."

Fibroblast

Related Topic
"...Fibroblasts produce collagen and elastin..."

Fluoride Toxicity

Relationship to Osteoporosis - Osteopenia
"Fluorides destroy collagen, which is the glue that adds strength to the bones..."

Glycine

Related Topic
"...A natural antacid and sweetener, it is involved in the syntheses of DNA, phospholipids and collagen..."

Glycolic Acid

As A Treatment
"...Once inside the cell, it stimulates the skin to make new, healthier collagen and elastin fibers in the deeper dermis, improving sun damage and wrinkling..."

Glycosylation

Related Topic
"...This protein cross-linking is characteristic of long-life proteins and is notable in the eye and in collagen..."

Gout / Hyperuricemia

Recommendation Increased Fruit/Vegetable Consumption
"...These compounds are flavonoid molecules that give these fruits their deep red-blue color, and are remarkable in their ability to prevent collagen destruction..."

Granulation

Related Topic
"Pink, fleshy overgrowth of capillaries and collagen within a wound..."

Grape Seed Extract

As A Treatment
"...The actions of PCOs include decreasing capillary permeability (vitamin "P"), inhibiting the breakdown of collagen, and free radical scavenging..."

Hawthorn Berry Extract

As A Treatment
"...Hawthorn is good for arthritis because it helps stabilize collagen, the protein found in joints that are destroyed by inflammatory diseases..."

Heparin

As A Treatment
"...Some conditions that appear to be sensitive to heparin include ... Arthritis (Inhibits cell accumulation, collagen destruction and angiogenesis)..."

Hives

The Condition
"...hepatitis B virus, candida albicans, streptococcal bacteria), collagen vascular diseases, autoimmune diseases or other metabolic disorders, cancer, psychological, hypothyroidism, polycythemia vera, protoporphyria (even without excessive sun exposure)..."

Hot Applications (Thermotherapy)

As A Treatment
"...Whirlpool baths promote vasodilation and help stretch collagen tissue..."

Hyperbaric Oxygen

As A Treatment
"...Collagen deposition and synthesis depend on an oxygen-dependent prolyl-hydroxylase hydroxylation of proline..."

Hypertension (High Blood Pressure)

The Condition
"...chronic glomerulonephritis or pyelonephritis, polycystic renal disease, collagen disease of the kidney, obstructive uropathy) or pheochromocytoma, Cushing's syndrome, primary aldosteronism, hyperthyroidism, myxedema, coarctation of the aorta, or renovascular disease..."

Increased Fruit/Vegetable Consumption

As A Treatment
"...In test tube and animal studies, they have been shown to protect collagen, one of the most important components of capillary walls..."

Keloid

Related Topic
"A nodular, firm, movable, nonencapsulated, often linear mass of scar tissue, tender and frequently painful, consisting of wide, irregularly distributed bands of collagen, usually occurring after trauma, surgery, a burn, or severe acne, more common among people of African orgin..."

L-Lysine

As A Treatment
"...It is necessary for proper growth and helps form collagen which comprises bone cartilage and connective tissues..."

L-Proline

As A Treatment
"Proline is a non-essential amino acid that aids in the production of collagen and helps reduce the loss of collagen due to the aging process..."

Mercury Toxicity (Amalgam Illness)

Relationship to Multiple Sclerosis
"...Mercury has long been linked to autoimmune diseases such as MS because of its affinity to attach to collagen tissue, which is the most common protein in the body..."

Mitral Valve Prolapse

Recommendation Magnesium
"...A magnesium deficiency ... hinders the mechanism by which fibroblasts degrade defective collagen (connective tissue abnormalities are common in mitral valve prolapse),..."

MSM (Methyl Sulfonyl Methane)

As A Treatment
"...Function; Reasons For Use MSM provides an essential sulfur foundation that the body needs to form proteins and collagen (connective tissue), synthesize and activate vitamins, produce enzymes and immunoglobulin, and maintain the immune system..."

Osteoarthritis

Recommendation Boron
"...It does alleviate and seems to cure arthritis either by acting against whatever organism may cause rheumatoid diseases and/or as a membrane catalyst that permits repair of damaged cartilage and collagen..."

Osteoporosis - Osteopenia

Recommendation Bone Density Scan
"...A new urine test utilizes the two most specific markers of bone resorption - the collagen crosslinks pyridinium/pyridinoline (PYD) and deoxypyridinium/deoxypyridinoline (DPYD or DPD) - to identify elevated levels of bone loss before excessive damage occurs..."

Poor/Slow Wound Healing

The Condition
"...Granulation occurs, which means that special cells called fibroblasts make collagen to fill in the wound..."

Relationship to Low HGH (Human Growth Hormone)
"...HGH stimulates the production of collagen, which sticks wounds together, strengthens weakened tissue, gives skin more elasticity and helps wounds of the skin or bone heal faster and stronger..."

Recommendation Superoxide Dismutase
"...SOD should be supplemented to encourage new tissue to grow, to enhance collagen, and to reduce swelling..."

Recommendation Gotu Kola
"...Centella improves collagen formation and angiogenesis [Shukla et al..."

Recommendation Topical Estrogen
"...Wound size, collagen levels, and fibronectin levels all improved with topical estrogen, indicating improved wound healing..."

Recommendation Copper
"...It works with vitamin C to create strong collagen, and it creates cross-links in collagen and elastin that give strength to proteins..."

Recommendation L-Arginine
"...In a clinical study published in a major medical journal, arginine supplementation significantly increased the amount of reparative collagen synthesized at the site of a "standard wound" (an incision 5cm long and 1mm in diameter, into which a catheter was inserted) made in healthy volunteers..."

Recommendation Vitamin C (Ascorbic Acid)
"Vitamin C is crucial for the proper function of the enzyme protocollagen hydroxylase which produces collagen, the primary constituent of the granulation tissue that heals a wound and the key component in blood vessel walls..."

Prolotherapy

As A Treatment
"...Fibroblasts increase in number at the sites of injection and over the course of four to six weeks secrete a substance called collagen which is a very strong and relatively inelastic substance..."

Rheumatoid Arthritis

Recommendation Boron
"...It does alleviate and seems to cure arthritis either by acting against whatever organism may cause rheumatoid diseases and/or as a membrane catalyst that permits repair of damaged cartilage and collagen..."

Silicon

Related Topic
"...Collagen, the protein glue that holds us together, contains silicon in silanolate form..."

Silicone Breast Implant Problems

The Condition
"...Autoantibodies to collagen and extracellular matrix proteins and abnormalities of cell-mediated immunity have been found in women with silicone implants and not in controls..."

Sjogren's Syndrome

The Condition
"...Scleroderma causes the body to accumulate too much collagen, a protein commonly found in the skin..."

Sulfur Requirement

The Condition
"...Sulfur is also a constituent of bones, teeth, and collagen (the protein in connective tissue)..."

Threonine

As A Treatment
"...Anti-aging; helps form Elastin and Collagen; supports the immune system; produces antibodies; helps digestive and intestinal tract function; boosts metabolism..."

Torn, weak, or Stretched Ligaments or Tendons

The Condition
"...The torn or strained ligament is really millions of tears of these strands which are molecules of collagen..."

Vitamin C

Related Topic
"...Vitamin C is important for maintenance of bones, teeth, collagen and blood vessels (capillaries), enhances iron absorption and red blood cell formation, helps in the utilization of carbohydrates and synthesis of fats and proteins, aids in fighting bacterial..."

Vitamin C Requirement

The Condition
"...It helps the body build and maintain collagen; heal wounds and bruises; keep the immune system healthy; maintain healthy bones, teeth, gums, red blood cells, and blood vessels; repair bone fractures..."





Last updated: Aug 15, 2009


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