 Risk factors for Colon Polyps:
Recommendations and treatments for Colon Polyps: | |  | | | Amino Acid / Protein |  Cysteine / N-Acetyl-Cysteine (NAC) | Supplementation with NAC has been shown to reduce the proliferation of certain cells lining the colon and may reduce the risk of colon cancer in people with recurrent polyps in the colon. [Estensen RD, Levy M, Klopp SJ, et al. N-acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps. Cancer Lett 1999;147: pp.109-14]. |
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Diet |
 Soy Isoflavones (genistein, daidzein)| | Men who eat one or more servings of soy per week reduce the risk of developing colon polyps by half. [ Am J Epidemiol 1996;44(11): pp.1015-25] |
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Drug |
NSAIDs| | Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) could act to prevent the development of polyps in the colon, which are precursors to most colorectal cancers. In one study, patients who took aspirin or other NSAIDs more than 15 times per month at some time during the five years prior to the study were defined as "regular users"; patients who never took medication more than 15 times per month were defined as "non-users". After accounting for factors such as diet, lifestyle and family medical history, Dr. Sandler found that regular users of aspirin and other NSAIDs were only half as likely to harbor colon polyps as non-users.
"Our study supports the idea that some mechanism in aspirin and other NSAIDs has a protective effect when it comes to colon cancer," said Dr. Sandler. "More significantly, our results indicate that this protective effect occurs early in the process of cancer development, helping us to pinpoint where in the cancer development sequence these drugs might work best." [ Gastroenterology, March 1998] |
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KEY | | Proven definite or direct link |  | | Strongly counter-indicative | | | May do some good | | | Likely to help |
GLOSSARY
Anti-inflammatory (Antiinflammatory)
Reducing inflammation by acting on body mechanisms, without directly acting on the cause of inflammation, e.g., glucocorticoids, aspirin.
Benign
Literally: innocent; not malignant. Often used to refer to cells that are not cancerous; they tend to grow slowly and don't spread (metastasize) like cancer tumors do.
Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.
Colon (Colonic)
The part of the large intestine that extends to the rectum. The colon takes the contents of the small intestine, moving them to the rectum by contracting.
Colonoscope (Colonoscopy)
A thin, flexible 'telescope' that is passed up from the anus in order to examine the bowels.
NAC
N-acetyl-l-cysteine. A sulfur compound that is a precursor of glutathione.
NSAID (NSAIDs)
Non-steroidal anti-inflammatory drug.
Polyp (Polyps)
A usually nonmalignant growth or tumor protruding from the mucous lining of an organ such as the nose, bladder or intestine, often causing obstruction.
Precursor (Precursors)
A biochemical substance, such as an intermediate compound in a chain of enzymatic reactions, from which a more stable or definitive product is formed.
Last updated: Jan 03, 2010
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