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Non-Hodgkin's Lymphoma
  Cancer, Non-Hodgkin's Lymphoma
 Signs, symptoms, indicators
 Conditions that suggest it
 Contributing risk factors
 Conditions suggested by it
 It can lead to...
 Treatment recommendations
 Prevention
 


Lymphoma is a general term for cancers that develop in the lymphatic system. Hodgkin's disease is one type of lymphoma, and all other lymphomas are grouped together and called non-Hodgkin's lymphoma. Lymphomas account for about 5% of all cases of cancer in the U.S. In non-Hodgkin's lymphoma, cells in the lymphatic system become abnormal. They divide and grow without any order or control, or old cells do not die as cells normally do. Because lymphatic tissue is present in many parts of the body, non-Hodgkin's lymphoma can start almost anywhere in the body. Non-Hodgkin's lymphoma may occur in a single lymph node, a group of lymph nodes, or in another organ. This type of cancer can spread to almost any part of the body, including the liver, bone marrow, and spleen.

Over the years, doctors have used a variety of terms to classify the many different types of non-Hodgkin's lymphoma. Most often, they are grouped by how the cancer cells look under a microscope and how quickly they are likely to grow and spread. Aggressive lymphomas, also known as intermediate and high-grade lymphomas, tend to grow and spread quickly and cause severe symptoms. Indolent lymphomas, also referred to as low-grade lymphomas, tend to grow quite slowly and cause fewer symptoms.

Incidence; Causes & Development; Risk Factors


The incidence of non-Hodgkin's lymphoma has increased dramatically over the last couple of decades. This disease has gone from being relatively rare to being the fifth most common cancer in the United States. At the time of writing, little is known about the reasons for this increase or about exactly what causes non-Hodgkin's lymphoma.

Doctors can seldom explain why one person gets non-Hodgkin's lymphoma and another does not. It is clear, however, that cancer is not caused by an injury, and is not contagious; no one can "catch" non-Hodgkin's lymphoma from another person.

By studying patterns of cancer in the population, researchers have found certain risk factors that are more common in people who get non-Hodgkin's lymphoma than in those who do not. However, most people with these risk factors do not get non-Hodgkin's lymphoma, and many who do get this disease have none of the known risk factors.

Signs & Symptoms
Symptoms of non-Hodgkin's lymphoma may also be caused by other, less serious conditions, such as the flu or other infections.

Diagnosis & Tests
If non-Hodgkin's lymphoma is suspected, a doctor asks about the patient's medical history and performs a physical exam. The exam includes feeling to see if the lymph nodes in the neck, underarm, or groin are enlarged. In addition to checking general signs of health, the doctor may perform blood tests. The doctor may also order tests that produce pictures of the inside of the body, including:A biopsy is needed to make a final diagnosis. A biopsy for non-Hodgkin's lymphoma is usually taken from a lymph node, but other tissues may be sampled as well. In some cases, an operation called a laparotomy may be performed. During this operation, a surgeon cuts into the abdomen and removes samples of tissue to be checked under a microscope.

If non-Hodgkin's lymphoma is diagnosed, the doctor needs to learn the stage, or extent, of the disease. Staging is a careful attempt to find out whether the cancer has spread and, if so, what parts of the body are affected. Treatment decisions depend on these findings.

The doctor considers the following to determine the stage of non-Hodgkin's lymphoma:
  • The number and location of affected lymph nodes
  • Whether the affected lymph nodes are above, below, or on both sides of the diaphragm
  • Whether the disease has spread to the bone marrow, spleen, or to organs outside the lymphatic system, such as the liver.
Treatment & Prevention
Eating well during cancer treatment means getting enough calories and protein to help prevent weight loss and regain strength. Good nutrition often helps people feel better and have more energy. Some people with cancer find it hard to eat a balanced diet because they may lose their appetite. In addition, common side-effects of treatment, such as nausea, vomiting, or mouth sores, can make eating difficult. Often, foods taste different. Also, people being treated for cancer may not feel like eating when they are uncomfortable or tired.

Treatment for non-Hodgkin's lymphoma depends on the stage of the disease, the type of cells involved, whether they are indolent or aggressive, and the age and general health of the patient. Non-Hodgkin's lymphoma is usually treated with chemotherapy, radiation therapy, or a combination of these treatments. In some cases, bone marrow transplantation, biological therapies, or surgery may be options. For indolent lymphomas, the doctor may decide to wait until the disease causes symptoms before starting treatment. Often, this approach is called "watchful waiting".

Bone marrow transplantation (BMT) may be a treatment option, especially for patients whose non-Hodgkin's lymphoma has recurred (come back). BMT provides the patient with healthy stem cells (very immature cells that produce blood cells) to replace cells damaged or destroyed by treatment with very high doses of chemotherapy and/or radiation therapy. The healthy bone marrow may come from a donor, or it may be marrow that was removed from the patient, treated to destroy cancer cells, stored, and then given back to the person following the high-dose treatment. Until the transplanted bone marrow begins to produce enough white blood cells, patients have to be carefully protected from infection. They usually stay in the hospital for several weeks.

Patients who have a bone marrow transplant face an increased risk of infection, bleeding, and other side-effects from the large doses of chemotherapy and radiation they receive. In addition, graft-versus-host disease (GVHD) may occur in patients who receive bone marrow from a donor. In GVHD, the donated marrow attacks the patient's tissues (most often the liver, the skin, and the digestive tract). GVHD can range from mild to very severe. It can occur any time after the transplant (even years later). Drugs may be given to reduce the risk of GVHD and to treat the problem if it occurs.

Biological therapy (also called immunotherapy) is a form of treatment that uses the body's immune system, either directly or indirectly, to fight cancer or to lessen the side effects that can be caused by some cancer treatments. It uses materials made by the body or made in a laboratory to boost, direct, or restore the body's natural defenses against disease. Biological therapy is sometimes also called biological response modifier therapy.

The side-effects caused by biological therapy vary with the specific type of treatment. These treatments may cause flu-like symptoms such as chills, fever, muscle aches, weakness, loss of appetite, nausea, vomiting, and diarrhea. Patients also may bleed or bruise easily, get a skin rash, or retain fluid. These problems can be severe, but they usually go away after treatment stops.

Surgery may be performed to remove a tumor. Tissue around the tumor and nearby lymph nodes may also be removed during the operation.





Signs, symptoms & indicators of Non-Hodgkin's Lymphoma:
Symptoms - Abdominal Pain  (Severe) abdominal discomfort

Symptoms - Gas-Int - General

  (Regular/frequent) unexplained vomiting
  Frequent/regular unexplained nausea

Symptoms - General

  Constant fatigue

Symptoms - Glandular

  (History of) swollen axillary nodes
 The most common symptom of non-Hodgkin's lymphoma is a painless swelling of the lymph nodes in the neck, underarm, or groin.

  (Frequent) cervical node swelling
 The most common symptom of non-Hodgkin's lymphoma is a painless swelling of the lymph nodes in the neck, underarm, or groin.

  Back-of-neck lymph node problems
 The most common symptom of non-Hodgkin's lymphoma is a painless swelling of the lymph nodes in the neck, underarm, or groin.

Symptoms - Metabolic

  Very great/moderate/major unexplained weight loss
  Frequent/occasional unexplained fevers

Symptoms - Skin - General

  Itchy skin

Conditions that suggest Non-Hodgkin's Lymphoma:
Autoimmune  Gluten Sensitivity / Celiac Disease
 Gluten sensitivity predisposes patients to the eventual development of lymphoma. If this relationship is re-stated as "cereal grains cause cancer" the implications are more easily understood. In addition, the incidence of undiagnosed celiac disease is higher among those with small-bowel lymphoma [Eur J Gastroenterol Hepatol 2000;12: pp.645-8]. There is evidence that strict adherence to a gluten-free diet will reduce the incidence of lymphoma.

Circulation

  Anemia (Iron deficiency)

Immunity

  HIV/AIDS

Skin-Hair-Nails

  Psoriasis
 People who suffer from the skin disease psoriasis are at an increased risk for cancer, according to a study ending in 2003 that involved 108,000 patients. Specifically, study authors found that patients with psoriasis had a nearly three-fold increased rate of lymphoma. Previous research had found an association between psoriasis and lymphoma. Doctors from the University of Pennsylvania studied whether the rate of lymphoma in patients with a history of psoriasis is different from the rate of lymphoma in patients without psoriasis. After reviewing records, researchers found all the patients with psoriasis who had lymphoma were treated with medications consistent with psoriasis treatment. While researchers conclude there is an association between psoriasis and lymphoma, they feel additional research needs to be done to determine if this association is related to psoriasis severity, psoriasis treatment or an interaction between these risk factors. [Archives of Dermatology, 2003;139: pp.1425-9]

  Night Sweats

Symptoms - Cancer

  Non-Hodgkin's lymphoma (confirmed)

Risk factors for Non-Hodgkin's Lymphoma:
Addictions  Cigarette Smoke Damage
 One study has found that, compared to men who had never smoked, men who had smoked had an elevated mortality rate for non-Hodgkin's, with a risk almost four-fold greater among the heaviest smokers.

Immunity

  Weakened Immune System
 Non-Hodgkin's lymphoma is more common among people with inherited immune deficiencies, autoimmune diseases, or HIV/AIDS, and among people taking immunosuppressant drugs following organ transplants.

Infections

  Epstein-Barr virus (EBV)
 Human T-lymphotropic virus type I (HTLV-1) and Epstein-Barr virus are two infectious agents that increase the chance of developing non-Hodgkin's lymphoma.

Personal Background

  Caucasian ethnicity
 Non-Hodgkin's lymphoma occurs more frequently in whites than in African-Americans.

Symptoms - Cancer

  History of non-Hodgkin's lymphoma

Symptoms - Environment

  History of herbicide exposure
 There is reasonable evidence suggesting occupational exposure to phenoxy herbicides could result in both Hodgkin's and non Hodgkin's lymphoma. These compounds act as growth regulators and cause destructive proliferation of tissues in plants.

  (History of/high) solvent exposure
 People who work extensively with or are otherwise exposed to certain chemicals, such as pesticides, solvents, or fertilizers, have a greater chance of developing non-Hodgkin's lymphoma.

Non-Hodgkin's Lymphoma suggests the following may be present:
Addictions  Cigarette Smoke Damage
 One study has found that, compared to men who had never smoked, men who had smoked had an elevated mortality rate for non-Hodgkin's, with a risk almost four-fold greater among the heaviest smokers.

Immunity

  Weakened Immune System
 Non-Hodgkin's lymphoma is more common among people with inherited immune deficiencies, autoimmune diseases, or HIV/AIDS, and among people taking immunosuppressant drugs following organ transplants.

Tumors, Malignant

  Cancer, General

Non-Hodgkin's Lymphoma can lead to:
Skin-Hair-Nails  Night Sweats

Recommendations and treatments for Non-Hodgkin's Lymphoma:
Botanical  Arabinogalactans

Diet

  Aspartame (Nutrasweet) Avoidance

Drug

  LDN - Low Dose Naltrexone
  Hydrazine Sulfate
 See the link between Cancer (General) and Hydrazine Sulfate.

Habits

  Tobacco Avoidance
 The following study suggests a link between cigarette smoking and non-Hodgkin's lymphoma. In 17,633 U.S. male insurance policy holders, 49 deaths from Hodgkin's lymphoma and 21 from multiple myeloma occurred during a 20 year follow-up. Men who had ever smoked cigarettes had an elevated mortality for non-Hodgkin's, with a risk almost fourfold greater among the heaviest smokers compared with those who used no tobacco.

Immunotherapy

  Antineoplaston Therapy

Mineral

  Selenium
 In evaluating 59 patients with lymphoid malignancies such as Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma and chronic lymphocytic leukemia, it was found that serum selenium concentrations were significantly lower in patients than in controls. The lower the selenium levels were, the worse the cancer turned out to be.

As deficient selenium levels are associated with an increased risk of cancers in general, ensuring adequate selenium intake and maximizing selenium status in the presence of an elevated cancer risk is appropriate.

Nutrient

  Butyrate

Oxygen / Oxidative Therapies

  Ozone / Oxidative Therapy
 Ozone assists in reversing opportunist malignancies such as non-Hogkins lymphoma (especially if pulmonary) and lymphadenopathy-associated virii.

Vitamins

  Vitamin D
 Administration of activated vitamin D (1,25 dihydroxycholecalciferol) may be beneficial in non-Hodgkin's lymphoma. Experimental Study: In a small trial, patients with non-Hodgkin's lymphoma who were found to have high levels of vitamin D receptors responded to activated vitamin D. [Cunningham D, Gilcrist NL, Cowan RA, et al. Vitamin D as a modulator of tumour growth in low grade lymphomas. Abstract. Scot Med J 30: p.193, 1985]

  Vitamin K
 Many patients on high dose chemotherapy for lymphoma or myeloma test positive for prothrombin precursor PIVKA II. These are proteins induced by vitamin K absence or antagonism.

Preventive measures against Non-Hodgkin's Lymphoma:
Detoxification  Sauna Detoxification Program
 Programs using low temperature environments (like special saunas) have clearly demonstrated the ability to reduce or remove chemicals commonly stored in the fatty tissues of modern man. Such chemicals include recreational drugs, pesticides, herbicides, and many solvents. These chemicals are often carcinogenic, and non-Hodgkin's lymphoma, in particular, has been linked to herbicide and pesticide exposure. By avoiding contact with these agents or removing them from a body already burdened with them, the risk of health consequences including non-Hodgkin's lymphoma should be reduced.

Diet

  Reduced Calorie Consumption
  Plant-Based Nutrition
 A high red meat and animal fat intake is associated with an increased risk of non-Hodgkin lymphoma in older women.

  Caffeine/Coffee Avoidance
 The consumption of coffee, tea and cola were all positively correlated with a higher risk of NHL.

Mineral

  Zinc
 It was found that the copper to zinc ratio was significantly higher in patients with lymphoma or acute and chronic leukemias compared to control subjects. A person at increased risk of one of these cancers should check blood levels of copper and zinc to rule out abnormalities and make adjustments accordingly. Since zinc and copper are antagonistic, and zinc deficiency is relatively common, supplemental zinc is often used to improve this ratio. Zinc helps block the absorption of copper and acts to remove accumulated copper from the body as well as prevent its accumulation. [Rev. Invest. Clin, Nov-Dec. 1995;47(6): pp.447-52]

Nutrient

  Beta-Carotene
 The diets of 358 white men and women with NHL and 1432 controls living in Nebraska were compared. Dietary carotene intake was inversely related to NHL risk in men but not in women. [Ward MH, Hoar ZS, Weisenburger DD, et al. Dietary factors and non-Hodgkin's lymphoma in Nebraska]

Vitamins

  Vitamin E
 Observational Study: Serum vitamin E concentrations were significantly lower in leukemia and lymphoma patients than in normal controls.

  Vitamin C (Ascorbic Acid)
 The diets of 358 white men and women with non-Hodgkin's lymphoma and 1,432 controls living in Nebraska were compared. When dietary vitamin C levels were low, the risk of non-Hodgkin's lymphoma in men increased. This correlation was not found in women. [Ward MH, Hoar ZS, Weisenburger DD, et al. Dietary factors and non-Hodgkin's lymphoma]


KEY
Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
May do some good
Likely to help


GLOSSARY

Abdomen (Abdominal)
That part of the body between the chest and the hips that contains the stomach, intestines, liver, bladder, pancreas and other organs.

Acute
An illness or symptom of sudden onset, which generally has a short duration.

AIDS
Acquired Immune Deficiency Syndrome. An immune system deficiency disorder that suddenly alters the body's ability to defend itself. The AIDS virus invades the T4 helper/inducer lymphocytes and multiplies, causing a breakdown in the body's immune system, eventually leading to overwhelming infection and/or cancer, with ultimate death.

Autoimmune Disease (Autoimmune, Autoimmunity)
One of a large group of diseases in which the immune system turns against the body's own cells, tissues and organs, leading to chronic and often deadly conditions. Examples include multiple sclerosis, rheumatoid arthritis, systemic lupus, Bright's disease and diabetes.

Biopsy
Removal of a sample of tissue from a living being for diagnosis. A pathologist later uses a microscope to look for certain features, such as cancer cells, in the sample. A fine-needle aspiration biopsy involves inserting a thin needle to remove a small amount of tissue, sometimes using CT or ultrasound to guide the needle. A core biopsy involves obtaining a sample of tissue with a thick needle or by inserting a thin, lighted tube (laparoscope) into a small incision in the abdomen. Another biopsy method is to remove tissue during an operation.

Bruise (Bruised, Bruising)
Injury producing a hematoma or diffuse extravasation of blood without breaking the skin.

Cancer
Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.

Carcinogen (Carcinogenic, Carcinogenicity)
Any agent that is cancer-causing.

Carotene
Converted into vitamin A in the body from a yellow pigment that has several forms (i.e., alpha-, beta-, and gamma-carotene).

Celiac Disease (Gluten Sensitivity)
A digestive disease that damages the small intestine and interferes with absorption of nutrients from food. People who have celiac disease cannot tolerate a protein called gluten. Common symptoms include diarrhea, increased appetite, bloating, weight loss, irritability and fatigue. Gluten is found in wheat (including spelt, triticale, and kamut), rye, barley and sometimes oats.

Chemotherapy
A treatment of disease by any chemicals. Used most often to refer to the chemical treatments used to combat cancer cells. Chemotherapy is usually given in cycles: a treatment period followed by a recovery period, then another treatment period, and so on. Most anticancer drugs are given by injection into a blood vessel (IV); some are given by mouth. Chemotherapy is a systemic therapy, meaning that the drugs enter the bloodstream and travel throughout the body. Usually, a patient has chemotherapy as an outpatient (at the hospital, at the doctor's office, or at home). However, depending on which drugs are given and the patient's general health, a short hospital stay may be needed.

Chronic (Chronicity)
Usually referring to chronic illness: Illness extending over a long period of time.

Copper
An essential mineral that is a component of several important enzymes in the body and is essential to good health. Copper is found in all body tissues. Copper deficiency leads to a variety of abnormalities, including anemia, skeletal defects, degeneration of the nervous system, reproductive failure, pronounced cardiovascular lesions, elevated blood cholesterol, impaired immunity and defects in the pigmentation and structure of hair. Copper is involved in iron incorporation into hemoglobin. It is also involved with vitamin C in the formation of collagen and the proper functioning in central nervous system. More than a dozen enzymes have been found to contain copper. The best studied are superoxide dismutase (SOD), cytochrome C oxidase, catalase, dopamine hydroxylase, uricase, tryptophan dioxygenase, lecithinase and other monoamine and diamine oxidases.

Diaphragm
The thin muscle under the lungs and heart that separates the chest from the stomach/abdomen.

Diarrhea
Excessive discharge of contents of bowel.

Epstein Barr Virus (EBV, Epstein-Barr Virus)
A virus that causes infectious mononucleosis and that is possibly capable of causing other diseases in immunocompromised hosts.

Hodgkin's Disease (Hodgkin's)
Cancer of the lymphatic system and lymph nodes.

Human Immunodeficiency Virus (HIV)
A retrovirus associated with onset of advanced immunodeficiency syndrome (AIDS).

Immune System (Immune Response, Immunity)
A complex that protects the body from disease organisms and other foreign bodies. The system includes the humoral immune response and the cell-mediated response. The immune system also protects the body from invasion by making local barriers and inflammation. The process may involve acquired immunity (the ability to learn and remember a specific infectious agent), or innate immunity (the genetically programmed system of responses that attack, digest, remove, and initiate inflammation and tissue healing).

Immunosuppressant
An agent that acts to suppress the body's natural immune response.

Immunotherapy
Techniques used to stimulate or strengthen a patient's own immune system.

Indolent
A sluggish and unresolving condition, often with ulcerations and necrosis.

Leukemia
Cancer of the lymph glands and bone marrow resulting in overproduction of white blood cells (related to Hodgkin's disease).

Liver (Hepatic)
The largest and one of the most complex organs of the body, the liver is responsible for much of the metabolism of fats, proteins and carbohydrates. It is the site of much of the body's detoxification. It is connected very closely with digestion and the regulation of blood sugar, among many other functions. Found behind the ribs on the right side of the abdomen, it has many important functions such as removing harmful material from the blood, making enzymes and bile that help digest food, and converting food into substances needed for life and growth. Hepatic: Pertaining to the liver.

Lung (Lungs, Pulmonary)
Organ of the body, located in the chest cavity which is designed to bring oxygen from the air into the blood stream, while also expelling carbon dioxide and other waste gases out of the body. Pulmonary: Related to the lungs.

Lymph Nodes (Axillary Nodes, Inguinal Nodes, Lymph Gland, Lymph Glands, Lymph Node, Lymphatic)
Small, bean-shaped nodes at various points throughout the body that function to filter the lymph fluid and attempt to destroy the microorganisms and abnormal cells which collect there. The most common locations are the neck (both sides and front), armpit (axillary) and groin (inguinal), but also under the jaw and behind the ears. Swollen or painful lymph nodes generally result from localized or systemic infection, abscess formation, or malignancy. Other causes of enlarged lymph nodes are extremely rare. Physical examination for lymph nodes includes pressing on them to check for size, texture, warmth, tenderness and mobility. Most lymph nodes can not be felt until they become swollen, and then will only be tender when pressed or massaged. A lymph node that is painful even without touching indicates greater swelling. Lymph nodes can usually be distinguished from other growths because they generally feel small, smooth, round or oval-shaped and somewhat mobile when attempts are made to push them sideways. Because less fat covers the lymph nodes in children, they are easier to feel, even when they are not busy filtering germs or making antibodies. Childrens' nodes enlarge faster, get bigger in response to an infection and stay swollen longer than an adult's. Also known (incorrectly) as lymph glands.

Lymphatic System
A network of vessels which collect fluid from the tissues of the body and return it to the blood. Lymphatic fluid (also called lymph) is rich in white blood cells that fight infection and an important part of the body's immune system.

Lymphoma (Lymphomas)
Any tumor of the lymphatic tissues.

Magnetic Resonance Imaging (MRI)
A technique used in diagnosis that combines radio waves and magnetic forces to produce detailed images of the internal structures of the body.

Nanoliter (nL)
0.000000001 or one billionth of a liter.

Nausea
Symptoms resulting from an inclination to vomit.

Precursor (Precursors)
A biochemical substance, such as an intermediate compound in a chain of enzymatic reactions, from which a more stable or definitive product is formed.

Protein (Proteins)
Compounds composed of hydrogen, oxygen, and nitrogen present in the body and in foods that form complex combinations of amino acids. Protein is essential for life and is used for growth and repair. Foods that supply the body with protein include animal products, grains, legumes, and vegetables. Proteins from animal sources contain the essential amino acids. Proteins are changed to amino acids in the body.

Prothrombin
Protein needed for clotting of the blood.

Psoriasis
An inherited skin disorder in which there are red patches with thick, dry silvery scales. It is caused by the body making too-many skin cells. Sores may be anywhere on the body but are more common on the arms, scalp, ears, and the pubic area. A swelling of small joints may go along with the skin disease.

Radiation Therapy (Radiotherapy)
The use of high-energy rays to kill cancer cells. Depending on the stage of the disease, treatment with radiation may be given alone or with chemotherapy. Radiation therapy is local therapy; it affects cancer cells only in the treated area. External radiation does not cause the body to become radioactive. Most often, treatment is given on an outpatient basis in a hospital or clinic.

Selenium
An essential element involved primarily in enzymes that are antioxidants. Three selenium- containing enzymes are antioxidant peroxidases and a fourth selenium-containing enzyme is involved in thyroid hormone production. The prostate contains a selenium-containing protein and semen contains relatively large amounts of selenium. Clinical studies show that selenium is important in lowering the risk of several types of cancers. In combination with Vitamin E, selenium aids the production of antibodies and helps maintain a healthy heart. It also aids in the function of the pancreas, provides elasticity to tissues and helps cells defend themselves against damage from oxidation.

Serum
The cell-free fluid of the bloodstream. It appears in a test tube after the blood clots and is often used in expressions relating to the levels of certain compounds in the blood stream.

Spleen (Splenectomy)
The largest organ of the lymphatic system in the body, located between the stomach and the diaphragm (the muscle below the lungs which provides the motion for breathing). It destroys old red blood cells, produces lymphocytes and plasma cells, and stores blood. It also has other as yet unknown functions. A splenectomy is the surgical removal of the spleen.

Staging
Although grading and the identification of cancer cell types help determine a patient's prognosis, most doctors believe that the cancer's stage is a better indicator of a patient's survivability. The grade of a cancer cell is an assessment of its appearance compared to that of a normal, healthy cell. Grading is done on a scale (such as 1 to 4) with grade 1 cells differing little from normal cells, typically spreading slowly, and having a good prognosis for treatment. The highest grade cells look extremely different and indicate an aggressive cancer with poor prognosis. Staging allows a physician to gauge the size and location of tumors by using information gathered from imaging studies such as CT scans and MRIs, and from pathology tests and physical examinations. Staging factors that influence a patient's prognosis are:



Tumor (Tumors, Tumour, Tumours)
An abnormal growth of tissue resulting from uncontrolled, progressive multiplication of cells and serving no physiological function; a neoplasm. Literally, a swelling; in the past the term has been used in reference to any swelling of the body, no matter what the cause. However, the word is now being used almost exclusively to refer to a neoplastic mass, and the more general usage is being discarded.

Virus (Viri, Viruses)
Any of a vast group of minute structures composed of a protein coat and a core of DNA and/or RNA that reproduces in the cells of the infected host. Capable of infecting all animals and plants, causing devastating disease in immunocompromised individuals. Viruses are not affected by antibiotics, and are completely dependent upon the cells of the infected host for the ability to reproduce.

Vitamin C (Ascorbic Acid)
A water-soluble antioxidant vitamin essential to the body's health. When bound to other nutrients, for example calcium, it would be referred to as "calcium ascorbate". As an antioxidant, it inhibits the formation of nitrosamines (a suspected carcinogen). Vitamin C is important for maintenance of bones, teeth, collagen and blood vessels (capillaries), enhances iron absorption and red blood cell formation, helps in the utilization of carbohydrates and synthesis of fats and proteins, aids in fighting bacterial infections, and interacts with other nutrients. It is present in citrus fruits, tomatoes, berries, potatoes and fresh, green leafy vegetables.

Vitamin D
A fat-soluble vitamin essential to one's health. Regulates the amount of calcium and phosphorus in the blood by improving their absorption and utilization. Necessary for normal growth and formation of bones and teeth. For Vitamin D only, 1mcg translates to 40 IU.

Vitamin E
An essential fat-soluble vitamin. As an antioxidant, helps protect cell membranes, lipoproteins, fats and vitamin A from destructive oxidation. It helps protect red blood cells and is important for the proper function of nerves and muscles. For Vitamin E only, 1mg translates to 1 IU.

Vitamin K
Helps the blood clot when the body is injured.

White Blood Cell (WBC, White Blood Cells)
A blood cell that does not contain hemoglobin: a blood corpuscle responsible for maintaining the body's immune surveillance system against invasion by foreign substances such as viruses or bacteria. White cells become specifically programmed against foreign invaders and work to inactivate and rid the body of a foreign substance. White blood cells are composed primarily of neutrophils, monocytes and lymphocytes. Lymphocytes are either T-cells or B-cells. T-cells (CD3 cells) are divided into T-helper (CD4 cells) and T-suppressor/cytotoxic (CD8 cells) cells.

X-rays (X-ray)
High-energy radiation used to take pictures of areas inside the body.

Zinc
An essential trace mineral. The functions of zinc are enzymatic. There are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals in which zinc has been found to be necessary include: enzymes and enzymatic function, protein synthesis and carbohydrate metabolism. Zinc is a constituent of insulin and male reproductive fluid. Zinc is necessary for the proper metabolism of alcohol, to get rid of the lactic acid that builds up in working muscles and to transfer it to the lungs. Zinc is involved in the health of the immune system, assists vitamin A utilization and is involved in the formation of bone and teeth.




Last updated: Dec 30, 2008


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